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A FIRST-IN-CLASS IMMUNOTHERAPY

AGAINST CANCER

LATEST NEWS: Altevax is awarded a 2,6 M€ package by BPI France. 
Click here to read our press release.

Altevax is committed to bringing its innovative anticancer technology to patients, to treat diseases that have no available cure today

Altevax is supported by:

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Pr Antoine Carpentier

Co-founder – Scientific Advisor

KEY FACTS

INNOVATION

Using melanin as an adjuvant, Altevax has developed an immunotherapy that triggers a strong antigen-specific immune response of CD8+ and CD4+ T cells

Applications in cancer (Clinical phase)

A treatment that can be produced simply at a reasonable cost

Worldwide patented technology

First results in humans expected in early 2025

TECHNOLOGY

HOW IT WORKS AND FIRST RESULTS

In many cases of cancer or infections, the main reason for the onset of the disease is the lack of a specific immune response. As a result, many therapies currently under development to treat these diseases (immunotherapies) aim at triggering the patient's immunity and mobilize their immune system.

Altevax immunotherapy triggers an immunity that...
...occurs fast...
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T-cell response in mice splenocytes

(nb of spots per 5x10  cells)

5

Altevax Peptide from Different Antigens.

T-cell response in mice splenocytes

(nb of spots per 5x10  cells)

5

...can be induced with peptides from different antigens and with various lengths...
...is between 6 to 30 times more efficient than current benchmark...
...and can eliminate tumours in cancer models
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T-cell response in mice splenocytes

(nb of spots per 5x10  cells)

5

Dose of peptide (gp100µg)

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Control Group (Saline)

No tumour reduction

pOVA30-IFA + CpG

Small tumour reduction and no cured mice

pOVA30-Mel + CpG (Altevax)

Significant tumour reduction and 25% cured mice

Unlike most current immunotherapies, Altevax technology combines efficiency and specificity

HOW IT WORKS

TECHNOLOGY

MAIN ADVANTAGES

Altevax technology allows to rapidly develop therapies against many diseases, leading to treatments that are easy to produce and administer

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  • The technology works with a wide range of peptide lengths, allowing for optimization between reactivity, specificity and manufacturability

  • Resulting treatments will have a much lower global cost (R&D + production) than alternatives of similar efficacy - such as autologous CAR-T therapies or last generation antiviral treatments

  • Melanin, the key ingredient, can be manufactured and combined with a specific peptide at a reasonable cost - process also patented by Altevax

STRONG POINTS
ACHIEVEMENTS

ACHIEVEMENTS

TECHNOLOGY

The Altevax immunotherapy is in clinical stage in Glioblastoma and preclinical stages across several disease models,reached key milestones on the critical path for ANSM/EMA approval for clinical trials:
  • Proof of concept - testing with consistently positive results on large number of samples (humanised mice) with wide range of peptides proving priming of CD8+ and CD4+ T cells

  • Characterisation of melanin, optimisation of the purification methods (> 99%)

  • Optimisation of the drug formulation and scale-up synthesis

  • Identification of target peptides for glioblastoma (GBM)

 

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TECHNOLOGY

IP AND RELEVANT SCIENTIFIC PUBLICATIONS

Altevax holds several patents and protects its technology and its use in diverse applications
  • Altevax is the exclusive worldwide licensee for the melanin technology patent
Relevant scientific publications:
IP & BIBLIOGRAPHY

THERAPEUTIC AREAS

APPLICATION & DEVELOPMENT STRATEGY

Over the last ten years, immunotherapy has greatly transformed the treatment of certain types of cancer. But the most advanced therapies stimulate the immune system in general and are not specific to the targeted disease. They are therefore difficult to control and have side effects.

Altevax is developing a novel immunotherapy using melanin as an adjuvant, linked to a peptide that is specific to the targeted disease. The revolutionary innovation lies in this unique combination, which offers both strong stimulation and high specificity. This gives the Altevax technology the potential to develop effective treatments for various types of cancer.

This new technology could revolutionize the field of immunotherapy.

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DEVELOPMENT STRATEGY

THERAPEUTIC AREAS

CANCER IMMUNOTHERAPY

Professor Antoine Carpentier has been working on glioblastoma for over 15 years. He discovered the immunostimulating power of melanin while working on this particularly aggressive brain cancer.

  • Today, glioblastoma treatment relies on surgery + radiotherapy + chemotherapy (temozolomide)

  • All current therapeutic approaches to glioblastoma under clinical investigation target natural cellular mechanisms that are shown to be misregulated in certain cancer cells. These approaches are thus non specific and tricky to balance as these mechanisms are also used by normal cells.

  • By stimulating the immune response against a peptide specific to glioblastoma, the Altevax approach mimics a physiological immune response, which most likely makes it specific, effective and well tolerated.

GLIOBLASTOMA KEY FACTS
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  • The most malignant among brain cancers, with a poor prognosis: survival rate of less than 5% within 5 years of diagnosis; life expectancy after diagnosis of 12-18 months.
     

  • No cure is available today, or in development. Palliative treatments are heavy for patients, have side effects and are expensive (cost of about $150,000/patient in the US including surgery)
     

  • GBM incidence is 2-3 new cases per 100,000 people per year, translating into about 80,000 new cases/year in the most developed countries. This incidence varies by country: about 14,000 cases/year in the US/Canada, 16,000 in the EU, 25,000 in China and 3,500 in Japan. The number of new cases in these countries is growing at an average 3% per year.
     

  • Total GBM market today estimated at $1.2 Billion*, growing at a 7.4% cagr* to reach over $3.5 Billion by 2035

                                                                                                                                  * Source: GlobalData GBM Study 2018

CANCER IMMUNOTHERAPY
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SCIENTIFIC TEAM

OUR PEOPLE

MANAGEMENT TEAM

SCIENTIFIC TEAM

BOARD OF ADMINISTRATORS

MANAGEMENT TEAM
BOARD OF ADMINISTRATORS

CAREERS

WORK AT ALTEVAX

Altevax is always looking for new talents to continue its research and bring its innovative solution to the market. Join us, and be part of a skilled and ambitious team.

CAREERS

CONTACT US

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Contact

Batoul Farhat - Head of Business Development

batoul.farhat@altevax.com

Altevax

55 avenue Marceau

75116 Paris

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